Article
Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.
Biochemistry - 6 Jul 2004
Xu Bin, Hu Shi-Quan, Chu Ying-Chi, Huang Kun, Nakagawa Satoe H, Whittaker Jonathan, Katsoyannis Panayotis G, Weiss Michael A
Abstract excerpt
How insulin binds to and activates the insulin receptor has long been the subject of speculation. Of particular interest are invariant phenylalanine residues at consecutive positions in the B chain (residues B24 and B25). Sites of mutation causing diabetes mellitus, these residues occupy opposite structural environments: Phe(B25) projects from the surface of insulin, whereas Phe(B24) packs against the core....
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