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Article

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

The Journal of biological chemistry - 30 Nov 2007

Huang Kun, Chan Shu Jin, Hua Qing-xin, Chu Ying-Chi, Wang Run-ying, Klaproth Birgit, Jia Wenhua, Whittaker Jonathan, De Meyts Pierre, Nakagawa Satoe H, Steiner Donald F, Katsoyannis Panayotis G, Weiss Michael A

Abstract excerpt

The contribution of the insulin A-chain to receptor binding is investigated by photo-cross-linking and nonstandard mutagenesis. Studies focus on the role of Val(A3), which projects within a crevice between the A- and B-chains. Engineered receptor alpha-subunits containing specific protease sites ("midi-receptors") are employed to map the site of photo-cross-linking by an analog containing a photoactivable A3 side...

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Identifiers

PMID: 17884811
DOI: 10.1074/jbc.M705996200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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