Article
Association of colonic and endometrial carcinomas in Portuguese families with hereditary nonpolyposis colorectal carcinoma significantly increases the probability of detecting a pathogenic mutation in mismatch repair genes, primarily the MSH2 gene.
Cancer - 1 Jul 2004
Lage Pedro A, Albuquerque Cristina, Sousa Rita G, Cravo Marilia L, Salazar Maria, Francisco Inês, Maia Lara, Claro Isabel, Suspiro Alexandra, Rodrigues Paula, Raposo Hélder, Fidalgo Paulo A, Nobre-Leitão Carlos
Abstract excerpt
BACKGROUND: Hereditary nonpolyposis colorectal carcinoma (HNPCC) significantly raises the risk of developing colorectal carcinoma (CRC) and other extracolonic tumors. It is defined by the Amsterdam Criteria and is associated with germline mutations in mismatch repair genes, primarily MLH1 and MSH...
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