Replication of Herpes Simplex Virus 1 Depends on the γ ₁ 34.5 Functions That Facilitate Virus Response to Interferon and Egress in the Different Stages of Productive Infection

Abstract excerpt

The ability of the gamma(1)34.5 protein to suppress the PKR response plays a crucial role in herpes simplex virus pathogenesis. In this process, the gamma(1)34.5 protein associates with protein phosphatase 1 to form a large complex that dephosphorylates eIF-2alpha and thereby prevents translation shutoff mediated by PKR. Accordingly, gamma(1)34.5 null mutants are virulent in PKR-knockout mice but not in wild-type...

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