Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection

15 Dec 2011

Abstract excerpt

The γ(1)34.5 protein of herpes simplex viruses (HSV) is essential for viral pathogenesis, where it precludes translational arrest mediated by double-stranded-RNA-dependent protein kinase (PKR). Paradoxically, inhibition of PKR alone is not sufficient for HSV to exhibit viral virulence. Here we report that γ(1)34.5 inhibits TANK binding kinase 1 (TBK1) through its amino-terminal sequences, which facilitates viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22171259
DOI: 10.1128/jvi.05376-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive InfectionPMID 22171259Read ↗

Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1.Semantic proximity Read ↗

Replication of Herpes Simplex Virus 1 Depends on the γ <sub>1</sub> 34.5 Functions That Facilitate Virus Response to Interferon and Egress in the Different Stages of Productive InfectionSemantic proximity Read ↗

An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity.Semantic proximity Read ↗

Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon productionSemantic proximity Read ↗

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.Semantic proximity Read ↗

Herpes simplex virus 1 encodes a STING antagonist that can be therapeutically targetedSemantic proximity Read ↗

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN TranscriptionSemantic proximity Read ↗

Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23Semantic proximity Read ↗

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced ReactivationSemantic proximity Read ↗

Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal InfectionSemantic proximity Read ↗

Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon ResponseSemantic proximity Read ↗

Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.