Article
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 1995
Chou J, Chen J J, Gross M, Roizman B
Abstract excerpt
The protein encoded by the gamma 134.5 gene of herpes simplex virus precludes premature shutoff of protein synthesis in human cells triggered by stress associated with onset of viral DNA synthesis. The carboxyl terminus of the protein is essential for this function. This report indicates that the...
Topics
- Animals
- Cells, Cultured
- Eukaryotic Initiation Factor-2
- Genes, Viral
- Herpesvirus 1, Human
- Humans
- Mutation
- Phosphoproteins
- Phosphorylation
- Protein Biosynthesis
- Protein Serine-Threonine Kinases
- RNA, Messenger
- RNA, Viral