Article
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.
Journal of virology - 1 Nov 1998
Cassady K A, Gross M, Roizman B
Abstract excerpt
In herpes simplex virus-infected cells, viral gamma134.5 protein blocks the shutoff of protein synthesis by activated protein kinase R (PKR) by directing the protein phosphatase 1alpha to dephosphorylate the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha). The amino acid...
Topics
- Animals
- Cell Line
- Chlorocebus aethiops
- Enzyme Activation
- Eukaryotic Initiation Factor-2
- Genes, Viral
- HeLa Cells
- Herpesvirus 1, Human
- Humans
- Mutation
- Phosphorylation
- Poly I-C
- RNA-Binding Proteins
- Recombinant Fusion Proteins