Article
Control of TANK-binding kinase 1-mediated signaling by the gamma(1)34.5 protein of herpes simplex virus 1.
The Journal of biological chemistry - 9 Jan 2009
Verpooten Dustin, Ma Yijie, Hou Songwang, Yan Zhipeng, He Bin
Abstract excerpt
TANK-binding kinase 1 (TBK1) is a key component of Toll-like receptor-dependent and -independent signaling pathways. In response to microbial components, TBK1 activates interferon regulatory factor 3 (IRF3) and cytokine expression. Here we show that TBK1 is a novel target of the gamma(1)34.5 prot...
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