Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene.

Abstract excerpt

Earlier studies have shown that infection of human cells by herpes simplex virus 1 (HSV-1) results in the activation of RNA-dependent protein kinase (PKR) but that the alpha subunit of eIF-2 is not phosphorylated and that protein synthesis is unaffected. In the absence of the viral gamma(1)34.5 g...

Topics

• Animals
• Chlorocebus aethiops
• Enzyme Activation
• Gene Deletion
• Genes, Viral
• HeLa Cells
• Humans
• Phenotype
• Phosphorylation
• Protein Biosynthesis
• Protein Serine-Threonine Kinases