HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.

doi:10.2337/diabetes.53.7.1692

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Article

HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.

Diabetes - 1 Jul 2004

Tree Timothy I M, Duinkerken Gaby, Willemen Sabine, de Vries René R P, Roep Bart O

Abstract excerpt

HLA-DQ is strongly associated with genetic predisposition to type 1 diabetes. It is assumed that HLA-DQ molecules exert their effects on the disease via the presentation of peptides from islet autoantigens to CD4(+) T-cells, but little information regarding HLA-DQ-restricted, islet antigen-specific, autoreactive T-cells is available. To investigate the role of HLA-DQ in the immune response to islet autoantigens,...

Topics

Alleles
Antibodies, Monoclonal
Antibody Formation
Autoantigens
Cell Division
Child
Diabetes Mellitus, Type 2
Female
Genetic Predisposition to Disease
Glutamate Decarboxylase
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insulin

Islets of Langerhans

Isoenzymes

Male

T-Lymphocytes

Tetanus Toxoid

Source

Open in PubMed

Identifiers

PMID: 15220192
DOI: 10.2337/diabetes.53.7.1692

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