Article
Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects.
Diabetologia - 1 May 1997
Schloot N C, Roep B O, Wegmann D, Yu L, Chase H P, Wang T, Eisenbarth G S
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is the result of a T-cell mediated autoimmune beta-cell destruction, which is accompanied by autoantibodies. We analysed the cellular and humoral immune response to insulin and insulin peptides in patients with recent-onset IDDM, IDDM patients treated with insulin, non-diabetic first degree relatives and unrelated control subjects. There were no differences in T-cell...
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