Article
Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects.
Diabetologia - 1 May 1997
Schloot N C, Roep B O, Wegmann D, Yu L, Chase H P, Wang T, Eisenbarth G S
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is the result of a T-cell mediated autoimmune beta-cell destruction, which is accompanied by autoantibodies. We analysed the cellular and humoral immune response to insulin and insulin peptides in patients with recent-onset IDDM, IDDM patients treated wi...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acid Sequence
- Animals
- Autoantibodies
- Cells, Cultured
- Child
- Child, Preschool
- Conserved Sequence
- Diabetes Mellitus, Type 1
- Family
- Female
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Humans
- Insulin
