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Article

Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007

Monti Paolo, Scirpoli Miriam, Rigamonti Andrea, Mayr Anya, Jaeger Annika, Bonfanti Riccardo, Chiumello Giuseppe, Ziegler Anette G, Bonifacio Ezio

Abstract excerpt

Identifying beta cell autoantigen-reactive T cells that are involved in the pathogenesis of type 1 diabetes has been troublesome for many laboratories. Disease-relevant autoreactive T cells should be in vivo Ag experienced. The aim of this study was to test this hypothesis and then use this principle as a strategy for identifying diabetes-relevant autoreactive T cells. In this study, a CSFE dilution assay was...

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Identifiers

PMID: 17947651
DOI: 10.4049/jimmunol.179.9.5785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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