Article
Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.
Clinical and experimental immunology - 1 Dec 1998
Sarugeri E, Dozio N, Belloni C, Meschi F, Pastore M R, Bonifacio E
Abstract excerpt
Type 1 diabetes is associated with autoimmunity to insulin. Genetic susceptibility to type 1 diabetes is polygenic and includes the INS VNTR-IDDM2 locus which may regulate the expression of insulin in pancreas and thymus. In order to determine whether insulin autoimmunity could be attributed to a...
Topics
- Adolescent
- Adult
- Alleles
- Antibody Formation
- Autoantigens
- Autoimmunity
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Female
- HLA-DR3 Antigen
- HLA-DR4 Antigen
- Humans
- Immunity, Cellular
- Infant
- Insulin
- Islets of Langerhans
- Male