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Article

Autoimmune responses to the beta cell autoantigen, insulin, and the INS VNTR-IDDM2 locus.

Clinical and experimental immunology - 1 Dec 1998

Sarugeri E, Dozio N, Belloni C, Meschi F, Pastore M R, Bonifacio E

Abstract excerpt

Type 1 diabetes is associated with autoimmunity to insulin. Genetic susceptibility to type 1 diabetes is polygenic and includes the INS VNTR-IDDM2 locus which may regulate the expression of insulin in pancreas and thymus. In order to determine whether insulin autoimmunity could be attributed to a genetic susceptibility conferred by the INS VNTR-IDDM2 locus, peripheral blood T cell proliferation to human insulin...

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Identifiers

PMID: 9844045
DOI: 10.1046/j.1365-2249.1998.00744.x
PMCID: PMC1905134

Genes

INS

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Source receipt: pubmed, retrieved 7 Sept 2026.

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