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Article

Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1.

The Journal of biological chemistry - 17 Dec 2004

Fessenden James D, Feng Wei, Pessah Isaac N, Allen P D

Abstract excerpt

The functional relevance of putative Ca(2+) binding motifs previously identified with Ca(2+) overlay binding analysis within the skeletal muscle ryanodine receptor isoform (RyR1) was examined using mutational analysis. EF hands between amino acid positions 4081 and 4092 (EF1) and 4116 and 4127 (EF2) were scrambled singly or in combination within the full-length rabbit RyR1 cDNA. These cDNAs were expressed in 1B5...

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PMID: 15469935
DOI: 10.1074/jbc.M411136200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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