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Article

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury.

Kidney international - 1 Apr 2017

Oh Chang Joo, Ha Chae-Myeong, Choi Young-Keun, Park Sungmi, Choe Mi Sun, Jeoung Nam Ho, Huh Yang Hoon, Kim Hyo-Jeong, Kweon Hee-Seok, Lee Ji-Min, Lee Sun Joo, Jeon Jae-Han, Harris Robert A, Park Keun-Gyu, Lee In-Kyu

Abstract excerpt

Clinical prescription of cisplatin, one of the most widely used chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Since details of the underlying mechanisms are not fully understood, we investigated the role of pyruvate dehydrogenase kinase (PDK) in cisplatin-induced acute kidney injury. Among the PDK isoforms, PDK4 mRNA and protein levels were...

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Share to Membrane Potential, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28040265
DOI: 10.1016/j.kint.2016.10.011

Genes

PDK4
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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