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Article

Targeting expression of expanded polyglutamine proteins to the endoplasmic reticulum or mitochondria prevents their aggregation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004

Rousseau Erwann, Dehay Benjamin, Ben-Haïem Léa, Trottier Yvon, Morange Michel, Bertolotti Anne

Abstract excerpt

Aggregation of misfolded proteins is a characteristic of several neurodegenerative diseases. The huntingtin amino-terminal fragment with extended polyglutamine repeat forms aggregates closely associated with chaperones both in the cytoplasm and the nucleus. Because each cellular compartment conta...

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Identifiers

PMID: 15210964
DOI: 10.1073/pnas.0403015101
PMCID: PMC470729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15210964-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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