Article
Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q12.
Molecular psychiatry - 1 Mar 2003
McInnis M G, Lan T-H, Willour V L, McMahon F J, Simpson S G, Addington A M, MacKinnon D F, Potash J B, Mahoney A T, Chellis J, Huo Y, Swift-Scanlan T, Chen H, Koskela R, Stine O Colin, Jamison K R, Holmans P, Folstein S E, Ranade K, Friddle C, Botstein D, Marr T, Beaty T H, Zandi P, DePaulo J Raymond
Abstract excerpt
The purpose of this study was to assess 65 pedigrees ascertained through a Bipolar I (BPI) proband for evidence of linkage, using nonparametric methods in a genome-wide scan and for possible parent of origin effect using several analytical methods. We identified 15 loci with nominally significant evidence for increased allele sharing among affected relative pairs. Eight of these regions, at 8q24, 18q22, 4q32,...
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