Article
Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22.
American journal of human genetics - 1 Sept 2003
Fallin M Daniele, Lasseter Virginia K, Wolyniec Paula S, McGrath John A, Nestadt Gerald, Valle David, Liang Kung-Yee, Pulver Ann E
Abstract excerpt
Previous linkage studies in schizophrenia have been discouraging due to inconsistent findings and weak signals. Genetic heterogeneity has been cited as one of the primary culprits for such inconsistencies. We have performed a 10-cM autosomal genomewide linkage scan for schizophrenia susceptibility regions, using 29 multiplex families of Ashkenazi Jewish descent. Although there is no evidence that the rate of...
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