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Article

Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Valenti Luca, De Feo Tullia, Fracanzani Anna Ludovica, Fatta Erika, Salvagnini Mario, Aricò Sarino, Rossi Giorgio, Fiorelli Gemino, Fargion Silvia

Abstract excerpt

AIMS: To determine whether the functional A49G polymorphism of cytotoxic T-lymphocyte antigen-4 (CTLA-4), a T-cell surface molecule that modulates T-lymphocyte activation and influences the risk of developing alcohol-induced autoantibodies, plays a role in susceptibility to alcoholic liver disease (ALD) and influences disease severity in Italian alcohol abusers. METHODS: One hundred and eighty-three patients with...

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PMID: 15208156
DOI: 10.1093/alcalc/agh047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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