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Article

Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease.

European journal of gastroenterology & hepatology - 1 Nov 2007

Schott Eckart, Witt Heiko, Pascu Maria, van Boemmel Florian, Weich Viola, Bergk Alexandra, Halangk Juliane, Müller Tobias, Puhl Gero, Wiedenmann Bertram, Berg Thomas

Abstract excerpt

BACKGROUND: CTLA4 is an inhibitory receptor expressed on a subset of T lymphocytes. Single nucleotide polymorphisms of the CTLA4 gene have been implicated in autoimmune diseases, including autoimmune hepatitis and primary biliary cirrhosis. In reverse form, CTLA4 variations are associated with chronic infections such as chronic hepatitis B. METHODS: CTLA4 variations -318C>T and +49A>G were analyzed in 2366...

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Share to Cholangitis, Sclerosing
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Liver

Share to Hepatitis, Autoimmune

Share to Hepatitis B, Chronic

Share to Hepatitis, Chronic

Share to Liver Cirrhosis, Alcoholic

Share to Liver Cirrhosis, Biliary

Source

Identifiers

PMID: 18049163
DOI: 10.1097/MEG.0b013e3282efa240

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease.PMID 18049163Read ↗

Correlations of CTLA-4 gene polymorphisms and hepatitis C chronic infection.Semantic proximity Read ↗

Association of -319 C/T and +49 A/G polymorphisms of CTLA-4 gene in patients with hepatitis C virus infection.Semantic proximity Read ↗

+49A/G polymorphism of cytotoxic T‐lymphocyte antigen 4 gene in type 1 autoimmune hepatitis and primary biliary cirrhosis: A meta‐analysisSemantic proximity Read ↗

Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B.Semantic proximity Read ↗

Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis.Semantic proximity Read ↗

Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.Semantic proximity Read ↗

Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis.Semantic proximity Read ↗

Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-α and interferon-γ levels in patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Investigation of the relationship between CTLA4 and the tumor suppressor RASSF1A and the possible mediating role of STAT4 in a cohort of Egyptian patients infected with hepatitis C virus with and without hepatocellular carcinoma.Semantic proximity Read ↗

Meta-analysis: the relationship between CTLA-4 +49 A/G polymorphism and primary biliary cirrhosis and type I autoimmune hepatitis.Semantic proximity Read ↗

Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.Semantic proximity Read ↗

CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.Semantic proximity Read ↗

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