Article
Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population.
World journal of gastroenterology - 15 Oct 2004
Fan Lie-Ying, Tu Xiao-Qing, Cheng Qu-Bo, Zhu Ye, Feltens Ralph, Pfeiffer Thomas, Zhong Ren-Qian
Abstract excerpt
AIM: To investigate the association between Chinese patients with autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and the polymorphisms of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene promoter (-318) and exon 1 (+49). METHODS: CTLA-4 promoter (-318 T/C) and exon1 (+49A/G) polymorphisms were genotyped via restriction fragment length polymorphism methods in 62 Chinese AIH patients, 77...
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