Article
Cytotoxic T lymphocyte antigen-4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2013
van Gerven Nicole M F, de Boer Ynto S, Zwiers Antonie, van Hoek Bart, van Erpecum Karel J, Beuers Ulrich, van Buuren Henk R, Drenth Joost P H, den Ouden Jannie W, Verdonk Robert C, Koek Ger H, Brouwer Johannes T, Guichelaar Maureen M J, Vrolijk Jan M, Kraal G, Mulder Chris J J, van Nieuwkerk Carin M J, Bouma Gerd
Abstract excerpt
BACKGROUND & AIMS: Single nucleotide polymorphisms (SNP) in the Cytotoxic T lymphocyte antigen-4 gene (CTLA-4) have been associated with several autoimmune diseases including autoimmune Hepatitis (AIH). In this chronic idiopathic inflammatory liver disease, conflicting results have been reported on the association with a SNP at position +49 in the CTLA-4 gene in small patient cohorts. Here, we established the...
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