Article
ARF1 regulates Nef-induced CD4 degradation.
Current biology : CB - 22 Jun 2004
Fauré Julien, Stalder Romaine, Borel Christelle, Sobo Komla, Piguet Vincent, Demaurex Nicolas, Gruenberg Jean, Trono Didier
Abstract excerpt
BACKGROUND: The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. RESULTS: Here we report that the small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. We find that Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes. Furthermore,...
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