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Article

HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.

Molecular biology of the cell - 1 Jan 2004

Larsen Jakob E, Massol Ramiro H, Nieland Thomas J F, Kirchhausen Tomas

Abstract excerpt

HIV Nef has a number of important biological effects, including the down-modulation of several immunological important molecules (CD4, major histocompatibility complex [MHC] class I). Down-modulation of CD4 seems to be via clathrin-dependent endocytosis, whereas down-modulation of MHC class I remains unexplained. Several mutant proteins, including mutations in the small GTPase Arf6, have been used to probe...

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Identifiers

PMID: 14617802
DOI: 10.1091/mbc.e03-08-0578
PMCID: PMC307550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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