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Article

Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.

Neurochemical research - 1 Jul 2004

Pomara Nunzio, Willoughby Lisa M, Hashim Audrey, Sershen Henry, Sidtis John J, Wesnes Keith, Greenblatt David J, Lajtha Abel

Abstract excerpt

The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) in random sequence, 1-week apart. Cognitive assessment and plasma levels of pHVA, pMHPG, and...

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Source

Identifiers

PMID: 15202770
DOI: 10.1023/b:nere.0000026402.09466.54

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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