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Article

Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration.

Psychopharmacology - 1 May 2006

Pomara Nunzio, Facelle Thomas M, Roth Amy E, Willoughby Lisa M, Greenblatt David J, Sidtis John J

Abstract excerpt

RATIONALE: Retrograde facilitation (RF) refers to a paradoxical phenomenon in which recall of information presented before acute administration of agents generally associated with anterograde amnestic and sedative effects, such as benzodiazepines, is enhanced relative to a placebo condition. However, it is unclear whether this effect occurs in elderly individuals and if it is influenced by plasma drug levels,...

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Source

Identifiers

PMID: 16525857
DOI: 10.1007/s00213-006-0336-0

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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