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Article

Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2004

Pomara Nunzio, Willoughby Lisa M, Wesnes Keith, Sidtis John J

Abstract excerpt

The degree to which elderly adults experience cognitive impairments from centrally acting anticholinergic drugs is variable, but the cause of this variability is unknown. The present study examined the epsilon4 allele as a possible modulator of the effects of trihexyphenidyl hydrochloride (Artane...

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Identifiers

PMID: 14735126
DOI: 10.1038/sj.npp.1300305

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14735126-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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