Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between anticholinergic drugs and apolipoprotein E epsilon4 allele and poorer cognitive function in older cardiovascular patients: a cross-sectional study.

Journal of the American Geriatrics Society - 1 Mar 2009

Uusvaara Juho, Pitkala Kaisu H, Tienari Pentti J, Kautiainen Hannu, Tilvis Reijo S, Strandberg Timo E

Abstract excerpt

OBJECTIVES: To clarify the association between anticholinergic drugs and apolipoprotein E epsilon4 allele carrier status (APOE4) and cognitive dysfunction. DESIGN: Cross-sectional analyses of current drug use and cognitive functioning according to the baseline assessments of the Drugs and Evidence-Based Medicine in the Elderly Study. SETTING: Helsinki, Finland. PARTICIPANTS: Four hundred community-dwelling people...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Genetic Carrier Screening

Share to Geriatric Assessment

Share to Mental Status Schedule

Share to Neuropsychological Tests

Share to Psychometrics

Source

Identifiers

PMID: 19278396
DOI: 10.1111/j.1532-5415.2008.02129.x

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between anticholinergic drugs and apolipoprotein E epsilon4 allele and poorer cognitive function in older cardiovascular patients: a cross-sectional study.PMID 19278396Read ↗

The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk.Semantic proximity Read ↗

Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: the 3-city study.Semantic proximity Read ↗

Detailed cognitive function and use of drugs with anticholinergic properties in older people: a community-based cross-sectional study.Semantic proximity Read ↗

[Effect of anticholinergic drugs on cognitive impairment in the elderly].Semantic proximity Read ↗

Apolipoprotein E ε4 Modifies the Effect of Possible Anticholinergic Drugs on Incident Dementia: The Shanghai Aging Study.Semantic proximity Read ↗

Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication?Semantic proximity Read ↗

Antihypertensive medication is associated with less cognitive impairment in the very old with apolipoprotein-E epsilon4 allele.Semantic proximity Read ↗

Anticholinergic Drug Burden and Risk of Incident MCI and Dementia: A Population-based Study.Semantic proximity Read ↗

Increased anticholinergic challenge-induced memory impairment associated with the APOE-epsilon4 allele in the elderly: a controlled pilot study.Semantic proximity Read ↗

Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults.Semantic proximity Read ↗

ApoE-epsilon 4 allele and susceptibility to drug-induced memory impairment in the elderly.Semantic proximity Read ↗

Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.