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Article

Increased mental slowing associated with the APOE epsilon4 allele after trihexyphenidyl oral anticholinergic challenge in healthy elderly.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Feb 2008

Pomara Nunzio, Belzer Ken, Hernando Raymundo, De La Pena Corazon, Sidtis John J

Abstract excerpt

OBJECTIVES: The objectives of this study were to examine the relationship between APOE epsilon4 and subjective effects of trihexyphenidyl on measures reflecting sedation and confusion and to investigate the relationship between trihexyphenidyl-induced subjective effects and objective memory performance. METHODS: This study comprised 24 cognitively intact, health elderly adults (12 APOE epsilon4 carriers) at an...

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Source

Identifiers

PMID: 18239197
DOI: 10.1097/JGP.0b013e31815aff75

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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