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Article

The greater sensitivity of elderly APOE ε4 carriers to anticholinergic medications is independent of cerebrovascular disease risk.

The American journal of geriatric pharmacotherapy - 1 Jun 2012

Nebes Robert D, Pollock Bruce G, Perera Subashan, Halligan Edythe M, Saxton Judith A

Abstract excerpt

BACKGROUND: Recent studies found use of anticholinergic medications to be associated with greater performance decrements in older persons who carry an ε4 allele of the apolipoprotein E (APOE) gene than in those carrying only ε2 or ε3 alleles. OBJECTIVES: The present study examined whether the apparently greater behavioral toxicity of anticholinergic drugs in ε4 carriers may result from an increased risk of...

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Source

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Identifiers

PMID: 22534472
DOI: 10.1016/j.amjopharm.2012.03.003
PMCID: PMC3367111

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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