Article
Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays.
Environmental health perspectives - 1 Nov 2003
Au William W, Salama Salama A, Sierra-Torres Carlos H
Abstract excerpt
A major barrier to understanding the role of polymorphic DNA repair genes for environmental cancer is that the functions of variant genotypes are largely unknown. Using our cytogenetic challenge assays, we conducted an investigation to address the deficiency. Using X-rays or ultraviolet (UV) light, we irradiated blood lymphocytes from 80 nonsmoking donors to challenge the cells to repair the induced DNA damage,...
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