Article
Gender differences in genetic damage induced by the tobacco-specific nitrosamine NNK and the influence of the Thr241Met polymorphism in the XRCC3 gene.
Environmental and molecular mutagenesis - 1 Jul 2005
Hill Courtney E, Affatato Alessandra A, Wolfe Kevin J, Lopez Mirtha S, Hallberg Csilla K, Canistro Donatella, Abdel-Rahman Sherif Z
Abstract excerpt
The rapid increase in adenocarcinoma of the lung and mortality amongst women strongly suggests that gender differences exist in sensitivity to certain tobacco carcinogens. In the current study, we performed the mutagen-sensitivity assay, with the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to test the hypothesis that women are more sensitive to the genotoxic effects of NNK...
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