Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK.

Cancer letters - 16 Oct 2000

Abdel-Rahman S Z, El-Zein R A

Abstract excerpt

DNA repair plays a critical role in protecting the genome of the cell from the insults of cancer-causing agents such as those found in tobacco smoke. Reduced DNA repair capacity would, therefore, constitute a significant risk factor for smoking-related cancers. Recently, a number of polymorphisms in several DNA repair genes have been discovered, and it is possible that these polymorphisms may affect DNA repair...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to DNA Repair
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamine

Share to Lymphocytes

Share to Nitrosamines

Share to Sister Chromatid Exchange

Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 10974407
DOI: 10.1016/s0304-3835(00)00532-2

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK.PMID 10974407Read ↗

XRCC1 polymorphisms and head and neck cancer.Semantic proximity Read ↗

Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK.Semantic proximity Read ↗

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells.Semantic proximity Read ↗

Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.Semantic proximity Read ↗

Effect of polymorphisms in XRCC1, CCND1 and GSTM1 and tobacco exposure as risk modifier for oral leukoplakia.Semantic proximity Read ↗

XRCC1 polymorphism and lung cancer risk.Semantic proximity Read ↗

DNA-repair genetic polymorphisms and breast cancer risk.Semantic proximity Read ↗

Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity.Semantic proximity Read ↗

Gender differences in genetic damage induced by the tobacco-specific nitrosamine NNK and the influence of the Thr241Met polymorphism in the XRCC3 gene.Semantic proximity Read ↗

Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer.Semantic proximity Read ↗

The XRCC1 codon 399 Gln allele is associated with adenine to guanine p53 mutations in non-small cell lung cancer.Semantic proximity Read ↗

DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.