Article
Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children.
Journal of clinical pharmacology - 1 Jul 2004
Kennedy Mary Jayne, Abdel-Rahman Susan M, Kashuba Angela D M, Leeder J Steven
Abstract excerpt
Caffeine and dextromethorphan have been used successfully both alone and in combination to assess phenotype and enzyme activity in children of various ages. Previous pediatric phenotyping studies with these agents have used varying durations of urine collection. However, the minimum duration required for accurate phenotypic assessment with these compounds in children remains unknown. We calculated the cumulative...
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