Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1995

McQuilkin S H, Nierenberg D W, Bresnick E

Abstract excerpt

Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase-2 (NAT2) are hepatic enzymes that may activate some procarcinogens. Previous reports have determined CYP1A2 and NAT2 phenotypes by quantitating relative amounts of urinary caffeine and metabolites. However, a number of experimental issues with this approach remain. To address these, we measured caffeine and 4 metabolites in urine samples from 20 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to NAT2 gene

Share to Genetic Variation

Share to Oxidoreductases

Share to Phenotype

Share to Time Factors

Source

Identifiers

PMID: 7742721

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.PMID 7742721Read ↗

Caffeine metabolic ratios for the in vivo evaluation of CYP1A2, N-acetyltransferase 2, xanthine oxidase and CYP2A6 enzymatic activities.Semantic proximity Read ↗

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.Semantic proximity Read ↗

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.Semantic proximity Read ↗

Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?Semantic proximity Read ↗

NAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios.Semantic proximity Read ↗

Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations.Semantic proximity Read ↗

Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.Semantic proximity Read ↗

Urinary biomarkers for assessing dietary exposure to caffeine.Semantic proximity Read ↗

The effect of NAT2 genotype and gender on the metabolism of caffeine in nonsmoking subjects.Semantic proximity Read ↗

Validity of an ELISA for N-acetyltransferase-2 (NAT2) phenotyping.Semantic proximity Read ↗

[Phenotyping of cytochrome P-450 1A2 and N-acetyltransferase (NAT2) using the in vivo caffeine test as a tool for determining individual susceptibility to selected xenobiotics].Semantic proximity Read ↗

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.