Article
Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1995
McQuilkin S H, Nierenberg D W, Bresnick E
Abstract excerpt
Cytochrome P4501A2 (CYP1A2) and N-acetyltransferase-2 (NAT2) are hepatic enzymes that may activate some procarcinogens. Previous reports have determined CYP1A2 and NAT2 phenotypes by quantitating relative amounts of urinary caffeine and metabolites. However, a number of experimental issues with t...
Topics
- Adult
- Arylamine N-Acetyltransferase
- Caffeine
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Female
- Genetic Variation
- Humans
- Male
- Middle Aged
- Oxidoreductases
- Phenotype
- Spectrophotometry, Ultraviolet
- Theophylline
- Time Factors
- Uracil
- Xanthines