Article
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Clinical pharmacology and therapeutics - 1 Nov 2003
Chainuvati Siwaporn, Nafziger Anne N, Leeder J Steven, Gaedigk Andrea, Kearns Gregory L, Sellers Edward, Zhang Yanhua, Kashuba Angela D M, Rowland Elizabeth, Bertino Joseph S
Abstract excerpt
Previously, we have validated a 4-drug phenotyping cocktail, the "Cooperstown cocktail," using caffeine (cytochrome p450 [CYP] 1A2, N-acetyltransferase-2 [NAT2], and xanthine oxidase [XO]), dextromethorphan (CYP2D6), omeprazole (CYP2C19), and intravenous midazolam (hepatic CYP3A). Data suggest th...
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