Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of immunophilins with mammalian TRPC channels.

The Journal of biological chemistry - 13 Aug 2004

Sinkins William G, Goel Monu, Estacion Mark, Schilling William P

Abstract excerpt

Drosophila photoreceptor channels TRP and TRPL are held in a large signalplex by the scaffolding protein, INAD. Immunophilin FKBP59, another member of the signalplex, binds to both INAD and TRPL. Mutation P702Q or P709Q in the highly conserved TRPL sequence (701)LPPPFNVLP(709), eliminates TRPL interaction with FKBP59. The first leucylprolyl (LP) dipeptide in this region is conserved in mammalian TRPC channel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Baculoviridae
Share to Calcium Channels
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamine

Share to Insecta

Share to Precipitin Tests

Share to Tacrolimus Binding Proteins

Share to TRPC Cation Channels

Source

Identifiers

PMID: 15199065
DOI: 10.1074/jbc.M401156200

Genes

TRPC3
TRPC1
TRPC6
TRPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of immunophilins with mammalian TRPC channels.PMID 15199065Read ↗

Regulation of Drosophila TRPL channels by immunophilin FKBP59.Semantic proximity Read ↗

Formation of novel TRPC channels by complex subunit interactions in embryonic brain.Semantic proximity Read ↗

Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.Semantic proximity Read ↗

Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo.Semantic proximity Read ↗

FAP48, a New Protein That Forms Specific Complexes with Both Immunophilins FKBP59 and FKBP12Semantic proximity Read ↗

[Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis].Semantic proximity Read ↗

The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.Semantic proximity Read ↗

The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.Semantic proximity Read ↗

Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.Semantic proximity Read ↗

Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Semantic proximity Read ↗

Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

Multimer formation by FKBP-12: roles for cysteine 23 and phenylalanine 36.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.