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Article

The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2002

Harteneck Christian, Kuchta Sabina Naranjo, Huber Armin, Paulsen Reinhard, Schultz Günter

Abstract excerpt

In fly photoreceptor cells, light initiates a G protein-coupled phospholipase Cb-dependent signaling cascade that results in the depolarization of the cell membrane, which is mediated by the cation channels TRP and TRPL. Together with phospholipase Cb and an eye-specific protein kinase C, TRP is...

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Identifiers

PMID: 12206995
DOI: 10.1096/fj.02-0192fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12206995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.PMID 12206995Read ↗

Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.Semantic proximity Read ↗

New light on TRP and TRPL.Semantic proximity Read ↗

The roles of trp and calcium in regulating photoreceptor function in Drosophila.Semantic proximity Read ↗

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp.Semantic proximity Read ↗

The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex.Semantic proximity Read ↗

Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.Semantic proximity Read ↗

TRP and calcium stores in Drosophila phototransduction.Semantic proximity Read ↗

Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.Semantic proximity Read ↗

Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.Semantic proximity Read ↗

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors.Semantic proximity Read ↗

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Semantic proximity Read ↗

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors.Semantic proximity Read ↗

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