Article
Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator.
American journal of respiratory cell and molecular biology - 1 Feb 2004
Gupta Sanhita, Xie Junxia, Ma Jianjie, Davis Pamela B
Abstract excerpt
The function of the R domain of cystic fibrosis transmembrane conductance regulator (CFTR) has not yet been fully established. The cis-trans proline isomerase cyclophilin A stimulates channel activity, and stimulation depends on the presence of highly conserved prolines at positions 740, 750, and 759. When the prolines at these positions, which normally exist in the cis conformation, are locked into the trans...
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