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Article

Pathologic and therapeutic implications for the cell biology of parkin.

Molecular and cellular neurosciences - 1 May 2015

Charan Rakshita A, LaVoie Matthew J

Abstract excerpt

Mutations in the E3 ligase parkin are the most common cause of autosomal recessive Parkinson's disease (PD), but it is believed that parkin dysfunction may also contribute to idiopathic PD. Since its discovery, parkin has been implicated in supporting multiple neuroprotective pathways, many revolving around the maintenance of mitochondrial health quality control and governance of cell survival. Recent advances...

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PMID: 25697646
DOI: 10.1016/j.mcn.2015.02.008
PMCID: PMC4492119

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