Article
The PARK2 Mutation Associated with Parkinson's Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat.
BioMed research international - 1 Jan 2020
Ming Fengyu, Tan Jieqiong, Qin Lixia, Zhang Hainan, Tang Jianguang, Tan Xuling, Wang Chunyu
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease in middle-aged and elderly people. However, the etiology and pathogenesis of PD are still unclear and there is a lack of reliable biomarkers for early molecular diagnosis. Parkin (encoded by PARK2) is a ubiquitin E3 ligase that participates in mitochondrial homeostasis, the ubiquitin-proteasome pathway, oxidative stress response, and...
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