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Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

20 Aug 2008

Abstract excerpt

Parkinson's disease (PD) results from the death of specific neuronal populations in the CNS. Potential causative factors include environmental toxins and gene mutations that can combine to dysregulate the processing and degradation of alpha-synuclein. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through...

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PMID: 18715146
DOI: 10.1089/ars.2008.2228

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