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Article

Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype.

Oncotarget - 9 Aug 2016

Reed Karen R, Song Fei, Young Maddy A, Hassan Nurudeen, Antoine Daniel J, Gemici Nesibe-Princess B, Clarke Alan R, Jenkins John R

Abstract excerpt

BACKGROUND AND AIMS: Colorectal cancer (CRC) arises via multiple genetic changes. Mutation of the tumour suppressor gene APC, a key regulator of Wnt signalling, is recognised as a frequent early driving mutation in CRC. We have previously shown that conditional loss of Apc within the murine small intestine (Apcfloxmice) results in acute Wnt signalling activation, altered crypt-villus architecture and many...

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Share to Genes, APC
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

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Source

Open in PubMed Open full text

Identifiers

PMID: 27323825
DOI: 10.18632/oncotarget.10076
PMCID: PMC5239505

Genes

HMGB1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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