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Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

Biochemical and biophysical research communications - 9 Jul 2004

Tsuchiya Kiyoto, Gatanaga Hiroyuki, Tachikawa Natsuo, Teruya Katsuji, Kikuchi Yoshimi, Yoshino Munehiro, Kuwahara Takeshi, Shirasaka Takuma, Kimura Satoshi, Oka Shinichi

Abstract excerpt

Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed the genotypes of CYP2B6 and their contribution to plasma EFV concentrations in 35 EFV-treated patients in International Medical Center of Japan. The mean plasma EFV concentration of patients with CYP2B6 *6/*6 (Q172H and K262R) (25.4+/-7.5 microM, +/-SD, n = 2) was significantly higher than that of patients with genotypes *6...

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PMID: 15194512
DOI: 10.1016/j.bbrc.2004.05.116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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