Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26.

doi:10.1086/522175

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Article

Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 6 and 26.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Nov 2007

Gatanaga Hiroyuki, Hayashida Tsunefusa, Tsuchiya Kiyoto, Yoshino Munehiro, Kuwahara Takeshi, Tsukada Hiroki, Fujimoto Katsuya, Sato Isao, Ueda Mikio, Horiba Masahide, Hamaguchi Motohiro, Yamamoto Masahiro, Takata Noboru, Kimura Akiro, Koike Takao, Gejyo Fumitake, Matsushita Shuzo, Shirasaka Takuma, Kimura Satoshi, Oka Shinichi

Abstract excerpt

BACKGROUND: Efavirenz (EFV) is metabolized primarily by cytochrome P450 2B6 (CYP2B6), and high plasma concentrations of the drug are associated with a G-->T polymorphism at position 516 (516G-->T) of CYP2B6 and frequent central nervous system (CNS)-related side effects. Here, we tested the feasibility of genotype-based dose reduction of EFV. METHODS: CYP2B6 genotypes were determined in 456 human immunodeficiency...

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PMID: 17918089
DOI: 10.1086/522175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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