Article
Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic responses of patients treated with efavirenz-containing regimen.
Pharmacogenetics and genomics - 1 Aug 2022
Kassogue Yaya, Diakite Brehima, Maiga Mamoudou, Kassogue Oumar, Konate Issa, Tamboura Kadidiatou, Diarra Fousseyni, Diarra Zoumana, Sawadogo Mahamadou Karamoko, Goita Yaya, Sissoko Sidi Boula, Sissoko Adama Seydou, Guirou Nouhoum, Dehbi Hind, Nadifi Sellama, Bah Sekou, Traore Cheick Bougadari, Kamate Bakarou, Dao Sounkalo, Dolo Guimogo
Abstract excerpt
OBJECTIVES: The main objective of this study was to evaluate the effect of CYP2B6 and CYP3A4 polymorphisms on the virological and immunologic responses of HIV patients. A total of 153 HIV-positive patients were enlisted for the study. PATIENTS AND METHODS: Viral load and median CD4 T cell counts were evaluated at baseline and month 6 (M6). Samples were identified using TaqMan genotyping assays. RESULTS: The AG in...
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