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High plasma efavirenz concentration and CYP2B6 polymorphisms in Thai HIV-1 infections.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Sukasem Chonlaphat, Chamnanphon Montri, Koomdee Napatrupron, Puangpetch Apichaya, Santon Siwalee, Jantararoungtong Thawinee, Prommas Santirat, Chantratita Wasun, Manosuthi Weerawat

Abstract excerpt

Efavirenz is mainly metabolized by cytochrome P450 2B6 (CYP2B6). This study aimed to examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms and plasma efavirenz concentrations in an HIV-1 infected Thai population. Mid-dose plasma efavirenz concentration was determined at 12 weeks following the initiation of an antiretroviral therapy (tenofovir, lamivudine and efavirenz) in 100 Thai...

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Alkynes
Aryl Hydrocarbon Hydroxylases
Asian People
Benzoxazines
Cyclopropanes

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Cytochrome P-450 CYP2B6

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PMID: 23399569
DOI: 10.2133/dmpk.dmpk-12-rg-120

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