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Pharmacogenetic markers of CYP2B6 associated with efavirenz plasma concentrations in HIV-1 infected Thai adults.

British journal of clinical pharmacology - 1 Dec 2012

Sukasem Chonlaphat, Cressey Tim R, Prapaithong Pattamawan, Tawon Yardpiroon, Pasomsub Ekawat, Srichunrusami Chutatip, Jantararoungtong Thawinee, Lallement Marc, Chantratita Wasun

Abstract excerpt

AIMS: To investigate the frequency of CYP2B6 polymorphisms and the influence of haplotype structure on plasma efavirenz concentrations in Thai adults with HIV-1 infection. METHODS: Genotyping of nine single nucleotide polymorphisms (SNPs, c.64C>T, c.499C>G, c.516G>T, c.785A>G, c.1375A>G, c.1459C>T, g.3003T>C, g.18492C>T and g.21563C>T) of CYP2B6 were performed using real-time PCR-based allelic discrimination on...

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Alkynes
Antiretroviral Therapy, Highly Active
Aryl Hydrocarbon Hydroxylases
Benzoxazines
Cyclopropanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cytochrome P-450 CYP2B6

Oxidoreductases, N-Demethylating

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PMID: 22471906
DOI: 10.1111/j.1365-2125.2012.04288.x
PMCID: PMC3522814

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