Article
Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo.
Biochemical and biophysical research communications - 9 Jul 2004
Qi Jing, Wang Shubin, Liu Guying, Peng Hui, Wang Jinhong, Zhu Zhenping, Yang Chunzheng
Abstract excerpt
One of the major mechanisms of multidrug resistance (MDR) in cancer therapy is the overexpression of P-glycoprotein (Pgp). We previously reported that pyronaridine (PND), a synthetic quinoline derivative in the clinic for the treatment of malaria infections, was capable of reversing MDR phenotype in Pgp-overexpressing tumor cells. Here we further evaluated the reversal activity of PND using two Pgp-overexpressing...
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