Article
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.
Journal of medicinal chemistry - 27 Nov 2008
Jiménez-Alonso Sandra, Pérez-Lomas Antonio L, Estévez-Braun Ana, Muñoz Martinez Francisco, Chávez Orellana Haydee, Ravelo Angel G, Gamarro Francisco, Castanys Santiago, López Matías
Abstract excerpt
We have synthesized a set of bis-pyranobenzoquinones through a direct and highly efficient approach based on a double intramolecular domino Knoevenagel hetero Diels-Alder reaction. These bis-pyranobenzoquinone derivatives are compounds whose skeletons have similarities to those of some anticancer...
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